Objective of this study was to formulate directly compressible mouth dissolving tablets of piroxicam with sufficient mechanical integrity, content uniformity and acceptable palatability to assist patients of any age group for easy administration. Six batches of piroxicam disintegrating tablets were prepared by using various subliming agents in order to get required theoretical release profiles. Effect of varying concentrations of different subliming agent such as camphor, menthol on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in-vitro disintegrating time, wetting time and in-vitro drug release. The study reveals that the formulation prepared by direct compression F6 exhibits better dissolution, disintegration time and wetting time compared to the other orally disintegrating tablet prepared. Physical parameters of all the formulated tablets were within the acceptable limits. FTIR studies did not indicate any excipients incompatibility, either during mixing or after compression.
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